Preparation of Calebin-A Liposomes and its Antiproliferation in Human Cancer Cells
ثبت نشده
چکیده
Calebin-A is a curcuminoid compound isolated from turmeric. Herein, we investigated the antiproliferative effect of calebin-A liposomes on cell growth compared with calebin-A. In this study, the calebin-A liposomes were successfully prepared by thin film-sonication method. The antiproliferative activity was evaluated in mouse neuroblastoma Neuro-2a cells and human SW480 colorectal tumor cells. Calebin-A liposomes (CAL) exhibited relatively uniform particle size distribution and perfectly stable during storage period of 3 weeks. The growth of SW480 and N2A cell could be inhibited by CAL. Liposomes could be an effective delivery system to enhance the Calebin-A bioactivity. The results have an important implication for using calebin-A liposomes for colon cancer prevention and therapeutics.
منابع مشابه
Co-Administration of Curcumin and Bromocriptine Nano-liposomes for Induction of Apoptosis in Lung Cancer Cells
Background: In recent years, nanotechnology with modern advances in the macromolecular design of nano-carriers has proved to be helpful in the development of drugs delivery systems. This research represents a novel co-administration of nano-vehicles, known as liposomes. Liposomes efficiently encapsulate curcumin and bromocriptine (BR) in a polymer structure, which results in enhanced aqueous so...
متن کاملPreparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study
The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...
متن کاملPreparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study
The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...
متن کاملInvestigating lipopolymers based on polyethylenimine and nanoliposome for gene delivery to prostate cancer (PC3) cell line
Background: Non-viral Nano carriers such as liposomes and cationic polymers based on engineered properties are regarded in gene delivery field. Although these carriers do not have weaknesses of viral vectors, but they are less efficient than viruses and they still need to be improved as favorable gene delivery carriers. Amongst non-viral carriers, cationic liposomes have been proposed for clini...
متن کاملToxicity Effect of Hydro-Alcoholic Extract of Pistachio Hull and Its Liposomal Form on Liver Cancer Cells (HepG2)
Background and Objectives: Pistachio skin is rich in phenolic compounds and an inexpensive source of antioxidants, which can be a good option for combating cancer cells. The aim of this study was to determine the potential of pistacia vera hydroalcoholic extract and its liposomal form as a potential cytotoxic agent in HepG2 cell line, which is related to human liver cancer. Materials and Metho...
متن کامل